Medical anatomist, had aroused new life to the spa. Every year Isolino sent patients and personally came to follow, tried to improve the primitive structures. In 1586 was ready the first draft of his book on Ischia, in which he summarized his many experiences and the topography of the island and especially treated the individual sources and fumaroles. The Nitrodi source based on the book "De’ Rimedi Naturali che sono nell’isola di Pithecusa oggi detta Ischia".